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Singula Health Singula Health

Marc Lener, MD, Founder & CEO

I have spent my career on one question: what does this patient have, underneath the diagnosis?

Answering it early lets the right treatment follow, before a patient loses years to the wrong one.

I’m a board-certified psychiatrist, neuroscientist, and clinical researcher, trained at the National Institute of Mental Health, the University of Pennsylvania, and Mount Sinai. I practice psychiatry in New York City.

My patients’ histories rarely arrived as a clean diagnostic story. Symptoms and labels piled up, and the pattern underneath could take years to surface, even when the information was already there in a history, a family story, and a treatment record no one had put together.

Seeing that pattern early is what a psychiatrist trains for years to do: noticing which combinations deserve attention, and catching the moment ordinary-looking depression stops behaving like ordinary depression.

In our pilot practices, much of my work is translation. The physicians know their patients deeply, often over years. I read what the intake surfaces and tell them plainly what it means for the patient in front of them, the way I would for a colleague. The diagnosis and every decision stay with them.

I also know this as the child of a mother who carried the wrong diagnosis for years, and I saw what those years cost.

Singula is where that work goes now: a specialist’s pattern recognition, in the room where most of these decisions are made.

The people behind Singula Health.

Marc Lener, MD, Founder & CEO

Sole founder, board-certified psychiatrist, neuroscientist, and clinical researcher, and the author of the clinical framework behind the Care Companion. He is principal investigator on the primary care studies.

Kara Uchtman, Chief Operating Officer

Leads operations and product from pilot through scale, including commercial discovery and the operating cadence behind the studies.

Ophir Frieder, PhD, Founding Advisor

Professor of Computer Science, Georgetown University.

Marc’s research asks why people with the same diagnosis present and respond so differently.

Selected publications

Biological Psychiatry, 2017

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

How disruptions in the brain’s glutamate and GABA systems contribute to major depression, and how they relate to the rapid antidepressant response some patients have to ketamine.

Lener MS, Niciu MJ, Ballard ED, et al. Biol Psychiatry. 2017;81(10):886-897. PMID 27449797.

Drugs, 2017

Ketamine and Beyond: Investigations into the Potential of Glutamatergic Agents to Treat Depression

Which glutamate-targeting agents, beginning with ketamine, show promise as rapid-acting treatments for major depression and bipolar depression.

Lener MS, Kadriu B, Zarate CA Jr. Drugs. 2017;77(4):381-401. PMID 28194724.

Annals of the New York Academy of Sciences, 2015

In pursuit of neuroimaging biomarkers to guide treatment selection in major depressive disorder: a review of the literature

Whether brain imaging can identify markers that help a clinician choose among treatments for major depressive disorder.

Lener MS, Iosifescu DV. Ann N Y Acad Sci. 2015. PMID 25854817.

Journal of Affective Disorders, 2016

Cortical abnormalities and association with symptom dimensions across the depressive spectrum

Whether specific structural brain differences in depression line up with particular symptom dimensions across the depressive spectrum.

Lener MS, Kundu P, Wong E, et al. J Affect Disord. 2016;190:529-536. PMID 26571102.

Journal of Affective Disorders, 2018

Parsing the heterogeneity of depression: An exploratory factor analysis across commonly used depression rating scales

Which distinct symptom dimensions sit inside commonly used depression rating scales, and whether those dimensions respond to ketamine in different ways.

Ballard ED, Yarrington JS, Farmer CA, Lener MS, et al. J Affect Disord. 2018;231:51-57. PMID 29448238.

Affiliations

Dr. Lener also founded Singula Institute, an independent nonprofit that supports mental health research and education. The two organizations are separate, and collaborate on research where their work overlaps.

Elsewhere

Marc writes the Psychology Today column A Biopsychosocial Solution, and he talked about misdiagnosis and the future of psychiatry in an interview with Dr. Psych Mom. You can also connect with him on LinkedIn.

Talk with our team.