Building the evidence for treatments that fit the person.
Only about 3 in 10 patients reach remission on their first antidepressant. Every primary care visit that uses Singula adds to a consented, real-world record of how mental illness presents and what the clinician did next, the kind of record that can change that.
For treatment developers, trial sponsors, and partners.
One first-line choice has to fit many different illnesses.
Patients who share the same screening score and the same diagnosis can carry different illnesses underneath, and the field has had little structured, real-world evidence of which patients respond to which treatments.
Treatment by category
- Patients are grouped by broad diagnosis
- Which patients respond to which treatment stays unclear
- Trials recruit mostly through major academic centers
- Patients cycle through treatments until one works
- Psychotherapy choices rest on the same broad categories
Treatment by pattern
- Each consented visit characterizes the person, over time
- Developers can see who responds to what, and aim new treatments there
- Trial sponsors can reach matched patients through community practices
- The right treatment can reach the right patient through their own physician
- Psychotherapy fit can be studied alongside medication
The layers of the record.
Each Brief captures the person in four layers, every element traced to a specific patient response and a specific rule.
The structure is the same from one practice to the next, which is what makes one practice’s records comparable with another’s and lets the record be followed over time.
Prior episodes, prior treatment and how it went, family psychiatric history, hospitalization, and the timeline underneath the current presentation.
Attachment pattern, emotional awareness and regulation, impulsivity, temperament: the stable characteristics that shape how illness expresses itself in a particular person.
Which symptoms are present and how they cluster: activation, anhedonia, avoidance, intrusive thought content, sleep pattern, executive function.
Adverse childhood experiences, housing, income, work, isolation, stigma, and the specific triggers a person names.
What exists today.
The record starts with consented patients in real primary care visits.
- Structured phenotype data from primary care visits, each record tied to the clinical action taken at that visit
- A rule set and output schema that make one practice’s records comparable with the next
- Collection governed by informed consent, institutional review, and a site agreement
What the record makes possible.
What becomes possible as the record grows.
A field that can see, at scale, how illness presents and responds can show which patients today’s treatments are failing, and aim the next treatment there.
Precision psychiatry is still years off. The evidence it needs starts in the primary care visit, where the presentation and the clinical decision sit together.
Primary care already reaches patients a major academic center never will. A network of practices running the Care Companion could carry trial access to people who would otherwise never be routed to one.
The Brief captures the range of psychotherapy approaches a presentation calls for, so the fit between psychotherapies and patients can be studied alongside the fit of medications.
Only real patients, in real care, can build this record.
Every Brief comes from a consented patient answering as themselves, tied to what the clinician did next. That link between a real presentation and a real clinical decision is what makes the record useful.
Singula does not sell patient data, and innovation partnerships start as a conversation about study design and governance.
Sources
Talk with us about an innovation partnership.
The most useful conversations start before the record is large.